Dec 20, 2023 marked 6 years of the National Comprehensive Cancer Network (NCCN)—an alliance of leading academic cancer centres in the USA—working alongside the African Cancer Coalition (ACC), the American Cancer Society (ACS), and the Clinton Health Access Initiative, as part of Allied Against Cancer. The NCCN has for the third time updated the harmonised cancer guidelines, to provide treatment recommendations specific to sub-Saharan Africa.