KEY TAKEAWAYS
- The study aimed to investigate the prevalence of malignant and benign secondary neoplasms in NS lesions.
- Researchers noticed prophylactic early excision of NS lesions is crucial to prevent malignancy.
Nevus sebaceous (NS) is a rare congenital skin lesion affecting approximately 0.3% of all newborns. Although benign, NS lesions can harbor malignant secondary tumors. The published rate of development of these malignant tumors varies. This meta-analysis aimed to identify the rate of malignant and benign secondary neoplasms occurring in NS.
Siyuan Pang and the team aimed to assess a comprehensive analysis of the prevalence of malignant and benign secondary neoplasms within NS lesions, shedding light on the variability in tumor development rates.
They performed an inclusive analysis by conducting a literature search encompassing PubMed, Embase, and Web of Science databases from inception to April 2023. Eligible studies reporting the incidence or risk of secondary neoplasms in patients with NS were identified. Independent reviewers screened studies, extracted relevant data, and assessed the quality of included studies.
The primary outcome focused on determining the pooled incidence of secondary neoplasms. Studies with sample sizes exceeding 50 patients were considered for meta-analysis using the random-effects model.
About 28 studies were identified, 22 of which were eligible for meta-analysis. The overall rate of secondary neoplasms was 12.8% (95% confidence interval [Cl], 9.2%-17.6%). The rates of development of malignant and benign tumors were 2.4% (95% CI, 1.4%-4.1%) and 10.3% (95% CI, 7.5%-13.9%), respectively.
The rate of development of basal cell carcinoma was 1.7% (95% CI, 0.9%-3.2%), whereas the rate of the development of syringocystadenoma papilliferum was 3.6% (95% CI, 2.5%-5.3%) and that if trichoblastoma was 2.6% (95% CI, 1.7%-3.8%).
The study concluded that despite the low but existing risk of malignant tumor development within primary NS lesions, prophylactic early excision stands as a viable strategy to prevent secondary malignancies and mitigate associated cosmetic and functional challenges. Resection of NS lesions in childhood emerges as a pragmatic first-line option, acknowledging the potential for resulting scars.
No funding information was provided.
Source: https://pubmed.ncbi.nlm.nih.gov/38725109/
Pang S, Cevik J, Sreedharan S, et al. (2024). “Rate of Benign and Malignant Secondary Tumors Associated With Nevus Sebaceous: A Systematic Review and Meta-Analysis.” Ann Plast Surg. 2024 Jun 1;92(6):711-719. doi: 10.1097/SAP.0000000000003879. Epub 2024 May 9. PMID: 38725109.
