Key role of CD4+ T cells in determining CD8 function during CAR-T cell manufacture

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• Key role of CD4+ T cells in determining CD8 function during CAR-T cell manufacture

  Abstract

• CD8+ chimeric antigen receptor T cells manufactured in absence of CD4+ cells exhibit hypofunctional phenotype

  Background Cell culture conditions during manufacturing can impact the clinical efficacy of chimeric antigen receptor…

• Correction: Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors