KEY TAKEAWAYS
- The study aimed to evaluate the clinical effects of ERAS in patients with NSCLC undergoing VATS lobectomy.
- Researchers provided strong evidence for the effectiveness of ERAS guidelines in improving outcomes for patients undergoing VATS lobectomy.
Enhanced Recovery After Surgery (ERAS) guidelines are a set of evidence-based interventions and care measures aimed at optimizing recovery after surgery and reducing postoperative complications, including those in patients with non-small cell lung cancer (NSCLC).
Yinhui Xu and the team aimed to assess how ERAS measures and care bundles can reduce post-operative complications and enhance recovery for patients undergoing video-assisted thoracic surgery (VATS) lobectomy.
The study included 120 patients, divided into 2 groups including a control group receiving routine care and an observation group following ERAS guidelines. The ERAS group received a bundle of care, incorporating various evidence-based treatments and care measures.
Researchers collected data on baseline characteristics, clinical parameters, and postoperative outcomes for both groups.
There were no significant differences in gender, age, TNM stages, smoking, or drinking between the ERAS and non-ERAS groups (P> 0.05). Likewise, no significant differences were found in cardiac ejection fraction (≥50%), FEV1%, forced vital capacity (FVC), lymphocytes, neutrophils (%), or tumor diameter (P> 0.05).
However, significant differences were observed in FVC, FEV1%, DLCO SB, albumin, C-reactive protein, leukocytes, monocytes, lymphocytes (%), hemoglobin, and neutrophils between the 2 groups (P< 0.05). ROC analysis identified leukocytes, DLCO, CRP, FEV1%, monocytes, lymphocytes (%), neutrophils (%), and BMI as key predictors for ERAS effectiveness.
Cutoff values for leukocytes >12.5, FEV1% >112.9, monocytes >16.8 (109/L), and neutrophils >11.6 indicated a higher likelihood of rapid recovery in patients undergoing VATS lobectomy. Integrating ERAS measures with care bundles reduced extubation time to less than 5.5 days, VAS score to below 3.5, and post-operative hospital stay to under 10.5 days.
The study concluded that ERAS management measures based on care bundles can significantly enhance the prognosis for patients undergoing VATS lobectomy, reduce post-operative complications, and expedite safe rehabilitation.
Additionally, these measures can shorten hospital stays, lower overall healthcare costs, and ease social and family burdens. Notable differences may be linked to factors such as leukocytes, FEV1%, monocytes, and neutrophils.
No funding information was provided.
Source: https://pubmed.ncbi.nlm.nih.gov/39186349/
Xu Y, Liang G, Wang W, et al. (2024). “Clinical Effects of Enhanced Recovery after Surgery in Perioperative Period Patients with Video-Assisted Thoracoscopic Lobectomy.” Ann Ital Chir. 2024;95(4):583-592. doi:10.62713/aic.3386
