KEY TAKEAWAYS
- The study aimed to assess the impact of END on the prognosis and explore subgroup-specific biomarkers for pts with cT2N0 MS-SCC.
- The key outcomes of the study were to evaluate the effect of END on DSS and OS.
- Researchers validated that END did not confer significant survival benefits in cT2N0 MS-SCC.
Maxillary sinus squamous cell carcinoma (MS-SCC) is a rare malignancy, yet it constitutes the predominant cancer type affecting the nasal cavity and paranasal sinus. Due to its typically asymptomatic early stages, over 80% of newly diagnosed MS-SCC cases present at an advanced T3/4 stage. Standard curative treatment involves surgical intervention alongside radiotherapy, often complemented by chemotherapy.
Jingjing Wang and the team aimed to evaluate the effect of elective neck dissection (END) on the prognosis of patients (pts) diagnosed with cT2N0 MS-SCC and identify predictive factors associated with the occurrence of occult metastasis in this specific patient group.
Researchers conducted a retrospective analysis using SEER database data, focusing on pts diagnosed with cT2N0 MS-SCC. Those pts were divided into 2 groups: those who underwent END and those who did not.
They utilized data from the SEER database to investigate the impact of END on disease-specific survival (DSS) and overall survival (OS) in pts with cT2N0 MS-SCC.
About 180 pts meeting inclusion criteria were analyzed after exclusion based on specific parameters. The study employed propensity score matching to compare outcomes between pts who underwent END and those who did not. Statistical analyses included univariate and multivariable models, presenting HR with 95% confidence intervals (CI). Ethical approval and patient consent were waived due to the study’s use of publicly accessible data from the SEER database.
The study assessed the impact of END on DSS and OS using propensity score matching. Multivariate logistic regression analysis was employed to identify predictors of occult metastasis. In total, the study included 180 pts, with 40 cases undergoing END.
Results indicated that following propensity score matching, there were no significant differences in DSS OS rates between pts who underwent END and those who did not. Occult metastasis was observed in 9 pts, corresponding to a rate of 22.5%.
High-grade tumors were independently associated with a higher risk of occult metastasis compared to low-grade tumors (HR 1.52, 95% CI 1.17-2.00). Overall, cT2N0 MS-SCC exhibited an occult metastasis rate of 22.5%, with histologic grade identified as the primary determinant of occult metastasis.
These findings concluded that END did not provide a significant survival benefit in cT2N0 MS-SCC.
The study was funded by the Henan provincial Medical Science and Technology Research Project (No.LHGJ20220196) and Project of Science and Technology in Science and Technology Department of Henan Province (No. 232102310285).
Source: https://pubmed.ncbi.nlm.nih.gov/39004629/
Wang J, Fang Q, Zhang X, et al. (2024). “Role of elective neck dissection in cT2N0 maxillary sinus squamous cell carcinoma.” Sci Rep. 2024 Jul 14;14(1):16230. doi: 10.1038/s41598-024-66179-7. PMID: 39004629; PMCID: PMC11247074.
