[Comment] Long-term efficacy of ibrutinib–venetoclax for first-line treatment in chronic lymphocytic leukaemia

January, 01, 2024 | Select Oncology Journal Articles

The results of the primary endpoint of the GLOW study1 formed the basis for approval of ibrutinib (a BTK inhibitor) and venetoclax (a BCL-2 inhibitor) combination therapy for first-line treatment of chronic lymphocytic leukaemia. This approach is now integrated in clinical practice. However, the analysis of long-term data by Carsten U Niemann and colleagues,2 after a median observation time of nearly 4 years, can address several key questions that have arisen in the context of this therapy.

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