[Comment] Directed acyclic graphs to foster transparency and scientific dialogue

Cardiovascular diseases are among the most common late effects and causes of deaths in survivors of childhood cancer. The paper by Rawan A Hammoud and colleagues1 contributes to this crucial issue by describing the disease burden of non-major and major adverse cardiovascular events in long-term survivors of childhood cancer. Using the well-established St Jude Lifetime Cohort Study (SJLIFE),2 the authors have shown an increased risk of major adverse cardiovascular events in survivors with increasing cumulative burden of non-major adverse cardiovascular events, stressing the importance of early detection and prevention.