With the rising incidence of endometrial cancer, it is now the most common gynaecological cancer in high-income countries. Globally in 2020, 60 127 patients were diagnosed with endometrial cancer and 341 831 women died due to this disease.1 Particularly troubling is the growing mortality gap disproportionately affecting Black patients with endometrial cancer. New treatment strategies are needed to address both the existing inequalities in mortality among diverse populations and the rising incidence of endometrial cancer globally.