[Comment] Androgen receptor agonism in advanced oestrogen receptor-positive breast cancer

February, 02, 2024 | Select Oncology Journal Articles

The androgen receptor is expressed in a majority of oestrogen receptor-positive breast cancers, acting as both a promoter and inhibitor of tumour cell growth under various conditions of oestrogen stimulation.1 When oestrogen receptors are activated, androgen receptors act as a competitive binder, decreasing downstream oestrogen receptor activity. However, in the setting of treatment with endocrine therapy, androgen receptors can act as an accessory growth pathway to bypass oestrogen receptor blockade.

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