KEY TAKEAWAYS
- The study aimed to examine clinical and MRI features to distinguish POMTs from MOMCs before surgery in ovarian tumors patients.
- The results showed that MOMC patients often had bilateral involvement and elevated CEA levels, despite lacking malignant tumor history.
Ovarian cancer prompts investigation into clinical and MRI features to preoperatively distinguish primary ovarian mucinous malignant tumors (POMTs) from metastatic mucinous carcinomas involving the ovary (MOMCs).
Song-Qi Cai and the team conducted a study that aimed to examine clinical and MRI characteristics for distinguishing POMTs and MOMCs preoperatively in ovarian cancer using MRI and clinical data.
In this retrospective multicenter study, 61 patients diagnosed with 22 POMTs and 49 MOMCs between November 2014 and June 2023 were enrolled. Clinical and MRI characteristics were assessed and compared between POMTs and MOMCs. Univariate and multivariate analyses were conducted to identify significant variables distinguishing the two groups. These variables were used to create a predictive nomogram, and ROC curve analysis was performed to assess diagnostic accuracy.
About 35.9% of patients with MOMCs were diagnosed synchronously with primary carcinomas, while 25.6% had bilateral MOMCs, whereas all POMTs were unilateral. Significant differences were observed in the biomarker CEA between the two groups (P= 0.002).
Moreover, significant disparities were noted in several MRI features, including tumor size, configuration, enhanced pattern, number of cysts, honeycomb sign, stained-glass appearance, ascites, locular size diversity ratio (P= 0.005, OR = 1.31), and signal intensity diversity ratio (P= 0.10, OR = 4.01), which emerged as independent predictors for MOMCs. The combination of these independent criteria resulted in the largest area under the curve of 0.922, with a sensitivity of 82.3% and specificity of 88.9%.
The study concluded that patients with MOMCs often presented with bilateral involvement and elevated CEA levels, despite not always having a history of malignant tumors. In ovarian mucin-producing tumors, uniform locular sizes and signal intensities were indicative of predicting MOMCs. Funding was received by the Shanghai Municipal Health Commission.
Source: https://pubmed.ncbi.nlm.nih.gov/38481236/
Cai, SQ., Wu, MR., Ma, XL. et al. (2024) “Mucin-producing tumors of the ovary——preoperative differentiation between metastatic ovarian mucinous carcinoma and primary mucinous malignant tumors.” J Ovarian Res 17, 59 (2024). https://doi.org/10.1186/s13048-024-01382-8.
