KEY TAKEAWAYS
- The study aimed to investigate the utility of PROMIS-29 in assessing perioperative PH outcomes in cranial neurosurgery pts.
- Researchers concluded that incorporating the PROMIS-29 PH summary score can reliably predict short-term postoperative outcomes in brain tumor pts.
Patient-reported outcome measures (PROMs) play a growing role in evaluating brain cancer pts perioperative health. Sachiv Chakravarti and his team aimed to assess the utility of the PROM Information System 29 (PROMIS-29), which is widely validated for assessing global physical health (PH). However, its applicability in cranial neurosurgery remains uncertain.
Researchers performed an inclusive analysis of adult brain tumor patients (pts) undergoing resection at a single institution from January 2018 to December 2021. Patients were prospectively administered PROMIS-29 surveys during pre-operative visits. Construction of PH summary scores facilitated the determination of optimum prediction thresholds for length of stay (LOS), discharge disposition (DD), and 30-day readmission using the Youden index of associated receiver operating characteristic curves.
The bivariate analyses explored the distribution of low (z-score≤-1) versus high (z-score>-1) PH scores based on baseline characteristics. Logistic regression models were employed to quantify the association between pre-operative PH summary scores and post-operative outcomes.
About 157 brain tumor pts (mean age 55.4±15.4 years; 58.0% female; mean PH score 45.5±10.5) were identified in the study. Prolonged LOS was observed in 24.8% of cases, non-routine discharge disposition in 37.6%, and 30-day readmission in 19.1%.
The bivariate analysis revealed that pts with low PH scores were significantly more likely to be diagnosed with a high-grade tumor (69.6% vs 38.85%, P=0.010) and less likely to undergo elective surgery (34.8% vs 70.9%, P=0.002). Furthermore, low PH scores were associated with prolonged LOS (26.1% vs 22%, P<0.001), nonroutine discharge (73.9% vs 31.3%, P<0.001), and 30-day readmission (43.5% vs 14.9%, P=0.003). In multivariate analysis, low PH scores predicted greater LOS (OR=6.09, P=0.003), nonroutine discharge (OR=4.25, P=0.020), and 30-day readmission (OR=3.93, P=0.020).
The study concluded that the PROMIS-29 PH summary score is a valuable predictor for short-term postoperative outcomes in brain tumor pts, suggesting its potential integration into prospective clinical workflows. No funding information was available.
Source: https://link.springer.com/article/10.1007/s11060-024-04627-0#article-info
Chakravarti, S., Kuo, C.C., Kazemi, F. et al. “Preoperative patient-reported physical health-related quality of life predicts short-term postoperative outcomes in brain tumor patients.” J Neurooncol (2024). https://doi.org/10.1007/s11060-024-04627-0.
