KEY TAKEAWAYS
- The study aimed to investigate integrating PWR with ALBI and PALBI scores to enhance prognostic precision in patients with HCC.
- Researchers noticed that integrating PWR with PALBI significantly improves prognostic accuracy for early-stage HCC.
Enhancing prognostic evaluation in Hepatocellular Carcinoma (HCC) remains an unmet need, particularly in patients with preserved live r function.
Maha Elsabaawy and the team aimed to integrate the Platelet-to-White Blood Cell Ratio (PWR) with albumin-bilirubin (ALBI) and platelets-albumin-bilirubin (PALBI) scores to improve the assessment of mortality and treatment responses in patients with HCC.
They performed an inclusive analysis involving 262 patients with HCC, collecting basic data and following up for 1 year or until death. All prognostic scores were calculated by integrating the Platelet-to-White Blood Cell Ratio (PWR) with the ALBI and PALBI scores, examining their relationship with treatment responses and mortality rates in the patients.
About 69.5% of the patients were males, with a mean age of 59.6 ± 8.09 years. The predictive power of the integrated PALBI+PWR score at different time points—1 month (P 0.004), 3 months, and 6 months (P 0.004)—outperformed all other scores.
However, at the 12-month follow-up, the ALBI score demonstrated superiority over PALBI+PWR (AUC 0.631, 0.617). Regression analyses confirmed the strong performance of PALBI+PWR factors in influencing treatment response (P 0.009; OR 0.562 (0.365 – 0.867)). In terms of mortality prediction, PALBI+PWR exhibited the highest efficacy in regression analysis (P < 0.001; OR 2.451 (1.555 – 3.862)).
The study concluded that integrating PWR with the PALBI score significantly enhances prognostic precision in patients with HCC, providing improved predictive power for treatment responses and mortality in the early stages of HCC with preserved liver function.
No funding information was given for this source.
Source: https://pubmed.ncbi.nlm.nih.gov/39342584/
Elsabaawy M, Badran H, Ragab A, et al. (2024). “Optimizing Prognostic Precision in Hepatocellular Carcinoma: Integrating PWR with ALBI and PALPI Scores.” Asian Pac J Cancer Prev. 2024;25(9):3067-3072. Published 2024 Sep 1. doi:10.31557/APJCP.2024.25.9.3067
