KEY TAKEAWAYS
- The study aimed to investigate the association between folate intake and the risk of EC through a dose-response meta-analysis.
- Researchers noticed that increased folate intake reduces the risk of EC.
A common cancer in the female reproductive system is endometrial cancer (EC), which ranks second and third in terms of new cases and deaths among gynecological malignancies. Respectively, the folate intake and the risk of EC relation remain controversial.
Jiaye Long and the team aimed to explore the connection between folate consumption and EC, followed by a dose-response analysis.
They performed an inclusive analysis up until February 1, 2024, utilizing PubMed, EMBASE, the Cochrane Library, and Web of Science for a comprehensive literature search. Stata 14 software was employed to analyze the findings of the articles.
The study protocol was registered in PROSPERO (CRD42024505943), and the meta-analysis was conducted in accordance with PRISMA guidelines, focusing on patients with relevant data on folate intake and EC risk.
About 9 case-control studies and 6 cohort studies were included, comprising 379,570 participants and 8,660 EC cases. The highest level of folate consumption was linked to a 10% reduction in the occurrence of EC (relative risk [RR] = 0.90, 95% confidence intervals [CIs]: 0.78-1.05, I² = 63.2%) when compared to the lowest level of intake. The association demonstrated a statistically significant linear trend (P = .231), with a combined RR of 0.974 (95% CI: 0.968-0.981) for each daily intake of 50 µg folate.
The study concluded that higher folate intake may be associated with a reduced risk of EC.
No funding information was given for this source.
Source: https://pubmed.ncbi.nlm.nih.gov/39312350/
Long J, Wang D, Yang M, et al. (2024). “Folate intake and the risk of endometrial cancer: A dose-response meta-analysis. Medicine (Baltimore).” 2024;103(38):e39775. doi:10.1097/MD.0000000000039775
