KEY TAKEAWAYS
- The study aimed to investigate the potential of plant-derived serine protease inhibitors as novel therapeutics for enhancing treatment efficacy in metastatic melanoma.
- Researchers noticed that plant serine protease inhibitors potentially enhance melanoma treatment, warranting further exploration.
Metastatic melanoma is the deadliest form of skin cancer due to its aggressive spread and significant resistance to conventional therapies. This study focuses on exploring novel therapeutic approaches to combat this challenging disease.
Ana Paula De Araújo Boleti and the team aimed to assess the efficacy of plant-derived serine protease inhibitors in melanoma treatment, evaluating their potential to overcome existing treatment barriers and improve patient outcomes.
They performed an inclusive analysis of melanoma incidence globally, examining its staging phases and various types. They investigated the associated risk factors and assessed current therapeutic strategies. The study involved a comprehensive review of pharmacological treatments and their effectiveness in melanoma management, focusing on both existing methodologies and emerging approaches.
With the implementation of targeted therapies, significant improvements have been made in managing patients with melanoma. However, the emergence of resistance early in treatment has resulted in continued limitations in overall survival and progression-free periods.
The study concluded that plant serine protease inhibitors offer promising new insights into melanoma therapeutics, advocating for high-throughput drug screening and further investigation into the underlying mechanisms associated with the disease.
This study was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (FINEP), Fundação de Apoio ao Desenvolvimento do Ensino, and Ciência e Tecnologia do Estado do Mato Grosso do Sul. This study was financed in part by the Fundação Universidade Federal de Mato Grosso do Sul—UFMS/MEC—Brazil.
Source: https://pubmed.ncbi.nlm.nih.gov/39202970/
Boleti APA, Jacobowski AC, Monteiro-Alfredo T, et al. (2024). “Cutaneous Melanoma: An Overview of Physiological and Therapeutic Aspects and Biotechnological Use of Serine Protease Inhibitors.” Molecules. 2024;29(16):3891. Published 2024 Aug 16. doi:10.3390/molecules29163891
