KEY TAKEAWAYS
- The study aimed to investigate the association of BED to local tumor control in parasellar meningioma.
- Researchers revealed that BED and BED/margin absorbed dose ratio can predict local control after SRS in parasellar meningioma.
The use of biological effective dose (BED) is increasing in radiosurgical literature to analyze the outcome of stereotactic radiosurgery (SRS) for brain cancer. BED is replacing absorbed dose, but there is a lack of studies investigating the link between BED and local tumor control in parasellar meningioma.
Ahmed Shaaban and the team aimed to investigate the association of BED to local tumor control in parasellar meningioma.
A retrospective analysis was conducted on patients who underwent SRS for parasellar meningioma between 1995 and 2022. Demographic, clinical, and outcome data were collected, along with SRS parameters.
Researchers calculated target margin BED, both with and without a sub-lethal repair model. Additionally, the ratio of BED at the target margin to the absorbed dose at the target margin was calculated. Factors related to local control were further examined.
The study included 91 patients, with 20 (22.0%) males and 71 (78.0%) females. The median age was 55.0 years (IQR Q1, Q3: 47.5, 65.5 years). About 34 patients (37%) had undergone meningioma resection before SRS. The median follow-up time from SRS to last clinical follow-up or progression was 89 months, with 13 patients (14.3%) experiencing progression. Local tumor control rates at 3, 5, and 10 years were 98%, 92%, and 77%, respectively.
In Cox univariate analysis, significant factors included: number of prior surgical resections (HR = 1.82, 95% CI = 1.08–3.05, P= 0.024), BED (HR = 0.96, 95% CI = 0.92-1.00, P= 0.03), and BED/margin (HR = 0.44, 95% CI = 0.21–0.92, P= 0.028). A BED threshold above 68 Gy was significantly associated with tumor control (P= 0.04).
The study indicated that BED and the ratio of BED to margin absorbed dose can serve as predictors of local control following SRS in individuals with parasellar meningioma. Furthermore, optimizing the BED to exceed 68 Gy2.47 may result in improved long-term tumor control.
No funding was received.
Source: https://link.springer.com/article/10.1007/s11060-024-04804-1
Shaaban A, Pham D, Tos SM, et al. Biological effective dose as a predictor of local tumor control in stereotactic radiosurgery treated parasellar meningioma patients. J Neurooncol. 2024. Available at: https://doi.org/10.1007/s11060-024-04804-1
