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Impact of PORT on Outcomes in Advanced TESCC

The study aimed to investigate the long-term outcomes of locally advanced TESCC with and without postoperative radiotherapy. Researchers noticed that postoperative radiotherapy improves survival and reduces recurrence in patients with advanced T3-4 TESCC without neoadjuvant treatment. Ya Zeng and the team aimed to define the long-term outcomes and recurrence patterns of patients with […]

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BTN3A1 Drives Vγ9Vδ2 T Cell Exhaustion in Cervical Cancer

The study aimed to explore how BTN3A1 promotes Vγ9Vδ2 T cell exhaustion by upregulating NR4A2/3. The results showed BTN3A1 promotes T cell exhaustion by inducing NR4A2/3 in cervical cancer. Jian Liu and the team aimed to investigate how BTN3A1 in cervical cancer promotes Vγ9Vδ2 T cell exhaustion. Vγ9Vδ2 T cells are crucial for […]

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Inhibition of NF-κB/HIF-1α Pathway by Tyrosol in CRC

The study aimed to investigate the role of IVIM and DCE perfusion imaging in predicting treatment response in patients with CRC. Researchers noted that IVIM and DCE imaging are promising for predicting treatment response in patients with CRC after Neo-CRT. A complex malignancy that necessitates multimodal treatment strategies is Colorectal cancer (CRC), including […]

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Nomilin Targets PI3K/Akt Pathway in TNBC

The study aimed to explore how nomilin combats TNBC and to uncover its molecular mechanisms. The results showed that nomilin inhibits TNBC progression by targeting core proteins in the PI3K/Akt pathway. Zhixuan Wu and their team aimed to investigate the therapeutic potential of nomilin, a limonoid compound, in treating triple-negative breast cancer (TNBC). […]

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A 3D view of Gall Bladder Human Digestive System

Prognostic Value of Serum Fibronectin in NMIBC on BCG Therapy

The study aimed to assess serum fibronectin and gene polymorphisms as predictors of recurrence and treatment response in patients with NMIBC on BCG therapy. Researchers found elevated serum fibronectin predicts early recurrence in NMIBC but not BCG response. Bladder cancer remains a major health concern, prompting continuous research into new biomarkers and therapeutic […]

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Treatment of Recurrent Gastric Cancer

Meta-analysis of Global GIM Prevalence

The study aimed to estimate the global prevalence of GIM through a systematic review and meta-analysis. The results showed the global prevalence of GIM is high, requiring further investigation and attention. Sara Soroorikia and the team aimed to estimate the global prevalence of gastric intestinal metaplasia (GIM), a precancerous lesion that raises the […]

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Stories to Watch

Liver Cancer Cells Growth

Optimizing HCC Prognostic Precision with PWR ALBI and PALBI

The study aimed to investigate integrating PWR with ALBI and PALBI scores to enhance prognostic precision in patients with HCC. Researchers noticed that integrating PWR with PALBI significantly improves prognostic accuracy for early-stage HCC. Enhancing prognostic evaluation in Hepatocellular Carcinoma (HCC) remains an unmet need, particularly in patients with preserved live r function. […]

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Impact of Oral Antithrombotic on Urinary Recovery Post-RARP

The study aimed to investigate the effect of oral antithrombotic agents on urinary continence recovery after RARP. Researchers noticed that oral antithrombotic agents may hinder urinary continence recovery after RARP. A widely favored minimally invasive surgical option for treating prostate cancer. The increasing number of elderly patients is Robot-assisted radical prostatectomy (RARP), particularly […]

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NDV Strain AF2240 Induces Apoptosis in Leukemia Cells

The study aimed to assess apoptosis and morphological changes in WEHI 3B leukemia cells treated with NDV. The results showed that NDV strain AF2240 induces apoptosis and structural changes in WEHI 3B leukemia cells. Rola Ali-Saeed and the team aimed to explore the effects of Newcastle Disease Virus (NDV) strain AF2240 on myelomonocytic […]

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Lower frequencies of circulating suppressive regulatory T cells and higher frequencies of CD4+ naïve T cells at baseline are associated with severe immune-related adverse events in immune checkpoint inhibitor-treated melanoma

Lower frequencies of circulating suppressive regulatory T cells and higher frequencies of CD4+ naïve T cells at baseline are associated with severe immune-related adverse events in immune checkpoint inhibitor-treated melanoma

Background Immune-related adverse events (irAEs) are major barriers of clinical management and further development of immune checkpoint inhibitors (ICIs) for cancer therapy. Therefore, biomarkers associated with the onset of severe irAEs are needed. In this study, …

1222 Antigen-specific delivery of TCR and costimulatory signals by a protein scaffold selectively activates and markedly expands naïve MART-1-specific CD8+ T cells

1222 Antigen-specific delivery of TCR and costimulatory signals by a protein scaffold selectively activates and markedly expands naïve MART-1-specific CD8+ T cells

Background Adoptive cell transfer (ACT) shows promise as an immunotherapy for melanoma and other cancers. However, there are several challenges associated with ACT such as the logistical complexity and inconsistency when using patient-derived antigen-presenting cells for …

890 Nivolumab plus ipilimumab in anti-PD(L)-1 naïve and experienced HCC patients -- single institute experience in Taiwan

890 Nivolumab plus ipilimumab in anti-PD(L)-1 naïve and experienced HCC patients -- single institute experience in Taiwan

Background Immune checkpoint inhibitors (ICIs) are standard therapy for advanced hepatocellular carcinoma (HCC). However, the efficacy of combining nivolumab and ipilimumab in Anti-PD(L)-1 Naïve and Experienced HCC patients remains unclear. Methods We retrospectively reviewed 23 patients with advanced …

778 TILVANCE-301, a phase 3 study of lifileucel tumor-infiltrating lymphocyte (TIL) cell therapy combined with pembrolizumab (pembro) vs pembro alone in treatment-naïve unresectable or metastatic melanoma

778 TILVANCE-301, a phase 3 study of lifileucel tumor-infiltrating lymphocyte (TIL) cell therapy combined with pembrolizumab (pembro) vs pembro alone in treatment-naïve unresectable or metastatic melanoma

Background Novel early-line therapies for advanced (unresectable or metastatic) melanoma are needed to improve the rate of deep and durable responses and increase the proportion of patients with long-term benefit. TILVANCE-301 will evaluate the efficacy and …