KEY TAKEAWAYS
- The study aimed to characterize the clinical outcomes of LITT-cSRS in patients newly diagnosed with BM.
- The results revealed this case series as the first to describe LITT-cSRS for newly diagnosed BM, supporting safety and efficacy.
In the context of brain cancer, previous research has investigated the efficacy and safety of laser interstitial thermal therapy followed by consolidation radiosurgery (LITT-cSRS) for locally recurrent brain metastases after initial radiosurgery (BMRS).
Rajiv Dharnipragada and the team aimed to analyze the clinical outcomes of LITT-cSRS in patients recently diagnosed with BM.
The study retrospectively identified 10 consecutive cancer patients with newly diagnosed brain masses of unclear etiology between 2017 and 2023. These patients underwent stereotactic needle biopsy (SNB) and LITT simultaneously, followed by consolidation SRS (cSRS) with over 6 months of follow-up. Clinical and imaging outcomes were subsequently collected.
The results revealed the histology of the BM were in breast cancer (n = 3), melanoma (n = 3), non-small cell lung cancer (n = 3), and colon cancer (n = 1). No wound or procedural complications occurred, and all patients were discharged home with a median one-day hospital stay (range: 1–2 days). Corticosteroid therapy was discontinued in all patients by the one-month follow-up. Consolidation SRS was performed 12–27 days post-SNB + LITT (median: 19 days).
No subsequent emergency room presentations or readmissions occurred within 30 or 90 days. The Karnofsky Performance Score remained stable or improved at the three-month follow-up. With a median follow-up of 416 days ([13.8 months]; range: 199-1,096 days), 1 patient experienced local recurrence at 384 days ([12.8 months]) post-LITT-cSRS. Except for this patient, all others exhibited decreased FLAIR volume surrounding the LITT-cSRS-treated BM by the 6 month follow-up.
The study concluded that this case series is potentially the first to describe LITT-cSRS in the context of newly diagnosed BM. The presented results offer preliminary evidence supporting the safety and efficacy of LITT-cSRS, establishing a basis for future research endeavors.
No funding information was available.
Source: https://link.springer.com/article/10.1007/s11060-024-04712-4
Dharnipragada, R., Shah, R.A., Reynolds, M. et al. (2024). “Laser interstitial thermal therapy followed by consolidation stereotactic radiosurgery (LITT-cSRS) in patients with newly diagnosed brain metastasis.” J Neurooncol (2024). https://doi.org/10.1007/s11060-024-04712-4
