KEY TAKEAWAYS
- The study aimed to investigate the prognostic significance of miR-100, -125b, and -200b as potential markers for CRC pts.
- Researchers observed promising correlations between miR-125b and -200b levels, tumor stage, and lymph node metastasis in CRC patients; further investigation is still ongoing.
Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most prevalent cancer and the second leading cause of cancer-related mortality. Despite the importance of early detection and treatment, existing screening methods have limitations, necessitating the exploration of novel markers for enhanced diagnosis, prognosis, and treatment strategies. To address this critical gap, S Maliborska and her team conducted a study to evaluate the potential of microRNA (miR)-100, -125b, and -200b as prognostic markers for CRC.
Researchers performed an inclusive analysis on twenty blood serum samples obtained from CRC patients. The expressions of miR-100, miR-125b, and miR-200b were quantified using real-time polymerase chain reaction. Following normalization, the results underwent rigorous statistical analysis to discern patterns and associations, contributing valuable insights into the potential prognostic significance of these miR in CRC.
About the results, miR-125b and miR-200b expressions exhibited significant correlations with T (r = -0.51 and 0.6, respectively, P < 0.05) and N (r = 0.47 and -0.52, respectively, P< 0.05) stages in CRC patients. Additionally, miR-125b levels were 1.56 times higher in patients with regional lymph node metastases, while miR-200b levels were 1.59 times lower in the same group.
The study concluded that observed miR-125b and -200b levels, correlated with tumor stage and lymph node metastasis in CRC patients, underscore their potential as minimally invasive biomarkers for prognostic assessment. The imperative for further validation studies with larger participant cohorts is emphasized to enhance the clinical utility of these promising biomarkers in CRC prognosis.
No funding was provided for the study.
Source: https://pubmed.ncbi.nlm.nih.gov/38328846/
Maliborska S, Holotiuk V, Partykevych Y, et al. (2024). “PROGNOSTIC SIGNIFICANCE OF microRNA-100, -125b, AND -200b IN PATIENTS WITH COLORECTAL CANCER.” Exp Oncol. 2024 Feb 3;45(4):443-450. doi: 10.15407/exp-oncology.2023.04.443. PMID: 38328846.
