[Comment] Polygenic risk scores in cancer screening: a glass half full or half empty?

Current cancer screening programmes use age and sex to define the individuals most likely to benefit. However, cancer risk also varies widely between people according to their genetics, lifestyle, and other risk factors. The principle of risk-stratified screening, beyond age and sex, is already incorporated into guidelines by the National Institute for Health and Care Excellence (NICE)1 and others, for example through offering enhanced breast cancer screening to women with a family history of breast cancer.