KEY TAKEAWAYS
- The study aimed to evaluate clinical effectiveness and immune mechanisms of microtransplantation in elderly patients with AML.
- The results showed microtransplantation improved OS and DFS through NK cell activation and IFN-γ response.
Acute myeloid leukemia (AML) is a challenging disease for elderly patients, particularly due to poor survival rates with standard treatments. Alternative therapeutic options such as microtransplantation have shown promise in improving clinical outcomes.
Ting Jin and their team aimed to investigate the clinical efficacy and underlying mechanisms of microtransplantation in elderly patients newly diagnosed with AML.
Researchers conducted a retrospective study from 2012 to 2022, analyzing 40 patients aged over 60 with newly diagnosed AML. Patients were divided into 2 groups that were the one receiving microtransplantation (chemotherapy combined with donor peripheral blood stem cell injection) and the control group receiving chemotherapy alone.
The study measured the percentage of NK cells and IFN-γ levels using flow cytometry and ELISA, along with clinical outcomes such as complete remission (CR), overall survival (OS), and disease-free survival (DFS).
The results demonstrated that 60% of patients in the microtransplantation group achieved complete remission compared to the control group. microtransplantation patients also showed improved 2-year OS (61.8%) and DFS (51.6%). Flow cytometry indicated a significant increase in NK cells and IFN-γ levels after microtransplantation, suggesting immunologic mechanisms contributing to the improved outcomes.
The study concluded that microtransplantation improved complete remission, OS, and DFS in elderly patients with AML, potentially through enhanced NK cell activity and IFN-γ response.
The study was supported by 2022 Hubei Provincial Natural Science Foundation Youth Project (No. 2022CFB797) and China Primary Health Care Foundation (No. cphcf-2023-101).
Source: https://pubmed.ncbi.nlm.nih.gov/39320131/
Jin T, Gao F, Yan J, et al. (2024). “Microtransplantation improved outcomes in elderly patients with newly diagnosed acute myeloid leukemia: clinical efficacy and mechanisms analysis.” Hematology. 2024;29(1):2407096. doi:10.1080/16078454.2024.2407096
