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Flap Reconstruction Results in Longer Overall Treatment Time in Patients Treated with Surgery and Adjuvant Radiotherapy for Carcinoma of the Oral Cavity and Larynx

March, 03, 2024 | Select Oncology Journal Articles

imageObjective:

There is an inverse relationship between cancer cure and overall treatment time (OTT) in patients treated with surgical resection and radiotherapy (RT).

Methods:

OTT was evaluated based on the reconstruction procedure in 420 patients with oral cavity and larynx cancers treated with surgery and RT between 1991 and 2020.

Results:

With OTT >85 days, the difference between no versus yes flap reconstruction was ~20 percentage points and significant for all comparisons: primary closure (+/− skin graft), 49%, vs. rotation or free flap, 71% (P<0.0001); primary closure (+/− skin graft), 49%, versus free flap without bone, 66% (P=0.0358); and primary closure (+/− skin graft), 49%, versus free flap with bone, 82% (P<0.0001).

Conclusions:

The use of flap reconstructions results in substantial increases in OTT. Findings suggest a need to reevaluate current policies regarding the choice of reconstruction and starting RT sooner after surgery.

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