The celiac plexus is a network of nerves surrounding the celiac artery that transmits pain signals from the upper abdominal organs. Abdominal malignancies, notably pancreatic cancer, often cause debilitating pain by disrupting local anatomy and infiltrating the celiac plexus. Initial pain management involve opioids and adjunct medications, but as pain becomes refractory, additional strategies are required. Although celiac plexus neurolysis is commonly employed, randomised controlled trials comparing it with pharmacotherapy have yielded conflicting results.