An otherwise healthy 41-year-old man presented to Baptist Medical Center in San Antonio, TX, USA, in February, 2021, with severe worsening exertional dyspnoea, orthopnoea, paroxysmal nocturnal dyspnoea, and bilateral extremity oedema. Transthoracic echocardiogram identified a large pericardial effusion and cardiac tamponade for which he underwent an emergent pericardial window procedure with evacuation of 1·5 L of sanguinous fluid from the pericardial sac. 2 months following hospital discharge he was referred to the cardiology department of the University of Texas Medical Branch in Galveston, TX, USA, with severe recurrent symptoms.